I have had CF card corruption although it has been a long time. I believe it was back when I was using a Kodak camera and it was a frequent occurence. I don't believe it has ever happened to me since I switched to Canon though. I still don't think I'll ever go over a 4GB card because of my Kodak experience. While I have found software that allows me to recover my cards I'd just as soon not have to recover too many photos from a bad card as it is a slow process.
You have to do what you are comfortable doing, chances are you'll never have a problem.